When dogs feel anxious, restless, or stressed, many veterinarians prescribe Trazodone as part of treatment. Trazodone is an antidepressant in humans, but in veterinary care, it is often used to manage anxiety, post-surgery restlessness, and behavior issues in dogs.
Pet owners often have questions about the right Trazodone dosage for dogs, including dosage per pound, by weight in kilograms, and how 100mg tablets are used safely. In this article, we will explore dosage charts, side effects, and real-life examples so you can understand how this medication works for dogs.
What is Trazodone for Dogs?
Trazodone is a serotonin antagonist and reuptake inhibitor (SARI). While it was developed for humans as an antidepressant, veterinary medicine has adopted it to treat:
- Separation anxiety
- Noise phobias (fireworks, thunderstorms, loud noises)
- Travel stress
- Post-surgical restlessness (to keep dogs calm after surgery)
- Generalized anxiety disorders
Trazodone is not FDA-approved for dogs, but veterinarians prescribe it as an off-label medication. That means it has been studied and found safe in veterinary practice, but official labeling is for human use.
👉 According to the American College of Veterinary Behaviorists, trazodone is considered effective when used correctly and under vet supervision.
Trazodone Dosage for Dogs
The right dose depends on your dog’s weight, condition, and health history. Vets calculate dosage in milligrams per pound (mg/lb) or milligrams per kilogram (mg/kg).
General Guidelines
- Standard dose: 1.5 – 3.5 mg per pound (3.5 – 7.5 mg per kg)
- Frequency: Every 8 to 24 hours depending on the situation
- Tablet sizes available: 50mg, 100mg, 150mg, and 300mg
Always consult your vet before giving trazodone. Self-medicating can cause overdose or side effects.
Trazodone Dosage for Dogs Per Pound
Since many owners think in pounds, here’s a simple reference:
- Small dogs (10 lbs): 15 – 35 mg
- Medium dogs (30 lbs): 45 – 105 mg
- Large dogs (70 lbs): 105 – 245 mg
- Giant dogs (100 lbs+): 150 – 350 mg
If you have a 100mg tablet, it may need to be split for small dogs or combined for large dogs.
Trazodone Dosage Chart for Dogs (By Weight in Pounds)
Here is a detailed chart for quick reference.
| Dog’s Weight (lbs) | Low Dose (mg) | Moderate Dose (mg) | High Dose (mg) |
|---|---|---|---|
| 5 lbs | 7.5 mg | 10 mg | 15 mg |
| 10 lbs | 15 mg | 25 mg | 35 mg |
| 20 lbs | 30 mg | 50 mg | 70 mg |
| 30 lbs | 45 mg | 75 mg | 105 mg |
| 40 lbs | 60 mg | 100 mg | 140 mg |
| 50 lbs | 75 mg | 125 mg | 175 mg |
| 60 lbs | 90 mg | 150 mg | 210 mg |
| 70 lbs | 105 mg | 175 mg | 245 mg |
| 80 lbs | 120 mg | 200 mg | 280 mg |
| 90 lbs | 135 mg | 225 mg | 315 mg |
| 100 lbs | 150 mg | 250 mg | 350 mg |
👉 Dogs on the higher end of dosage are usually treated for severe anxiety or post-surgery cases.
Trazodone Dosage for Dogs (By Weight in Kilograms)
For those who measure in kg, here’s a chart:
| Dog’s Weight (kg) | Low Dose (mg) | Moderate Dose (mg) | High Dose (mg) |
|---|---|---|---|
| 2 kg | 7 mg | 10 mg | 15 mg |
| 5 kg | 17 mg | 25 mg | 35 mg |
| 10 kg | 35 mg | 50 mg | 70 mg |
| 15 kg | 52 mg | 75 mg | 105 mg |
| 20 kg | 70 mg | 100 mg | 140 mg |
| 25 kg | 87 mg | 125 mg | 175 mg |
| 30 kg | 105 mg | 150 mg | 210 mg |
| 35 kg | 122 mg | 175 mg | 245 mg |
| 40 kg | 140 mg | 200 mg | 280 mg |
| 45 kg | 157 mg | 225 mg | 315 mg |
This aligns with the 1.5 – 3.5 mg per pound range most vets follow.
100mg Trazodone for Dogs Dosage Chart
Many vets prescribe 100mg trazodone tablets because they are convenient for medium-to-large dogs.
Here’s how 100mg fits into dosing:
- 10–20 lbs dogs: Not suitable; requires splitting tablets into smaller doses
- 30 lbs dog: Usually ½ to 1 tablet (50mg–100mg)
- 50 lbs dog: 1–1.5 tablets (100mg–150mg)
- 70 lbs dog: 1.5–2.5 tablets (150mg–250mg)
- 100 lbs dog: 2–3.5 tablets (200mg–350mg)
If your dog is small, your vet may prescribe a compounded version (liquid or custom tablet size).
Trazodone for Dogs Side Effects
Like all medications, trazodone can cause side effects. Most dogs tolerate it well, but some may react differently.
Common Side Effects:
- Drowsiness
- Sedation
- Lethargy
- Gastrointestinal upset (vomiting, diarrhea)
Less Common Side Effects:
- Panting
- Agitation or paradoxical excitement
- Increased hunger or thirst
Rare but Serious Side Effects:
- Serotonin Syndrome (when combined with other serotonin drugs like fluoxetine)
- Symptoms: tremors, seizures, high temperature, rapid heart rate
- Collapse or fainting (especially with heart conditions)
If you notice unusual symptoms, contact your vet immediately.
Real-Life Case Study: Trazodone in Dogs
Case Example: Bella, a 45-lb Border Collie
Bella had severe anxiety during thunderstorms. Her vet prescribed 100mg trazodone, once daily during storm season. Within an hour of taking it, Bella became calmer and no longer tried to hide or destroy furniture.
Case Example: Max, a 90-lb Labrador after Surgery
Max had ACL surgery and needed to stay calm during recovery. His vet prescribed 200mg trazodone every 12 hours. This helped Max rest, preventing him from running or injuring his stitches.
These real-life cases show how dosage varies by weight and purpose.
Safety Tips for Giving Trazodone to Dogs
- Follow vet prescription only – Never guess dosage.
- Check for drug interactions – Trazodone can interact with fluoxetine, clomipramine, and some pain medications.
- Monitor behavior – Track drowsiness, appetite, and mood.
- Don’t stop suddenly – Long-term users may need tapering to avoid withdrawal.
- Store safely – Keep tablets away from kids and pets.
FAQs on Trazodone for Dogs
1. Can I give my dog trazodone daily?
Yes, some dogs take it daily for chronic anxiety. Others take it only before stressful events (travel, fireworks, vet visits).
2. How fast does trazodone work?
Usually within 30 to 60 minutes. Peak effect happens after 2 hours.
3. How long does trazodone last in dogs?
Around 6 to 12 hours, depending on the dose and the dog’s metabolism.
4. Is trazodone safe for puppies?
Vets may prescribe it for puppies, but careful dosing is required since puppies are more sensitive.
5. Can I give my dog 100mg trazodone without a vet?
No. Dosage depends on weight and health history. Always consult a veterinarian first.
Backlinks for Further Reading
- American Veterinary Medical Association (AVMA) – Medication Use in Dogs
- VCA Animal Hospitals – Trazodone for Dogs
- PetMD – Trazodone for Dogs
Final Thoughts
Trazodone is a commonly prescribed medication that helps dogs manage anxiety, stress, and post-surgical rest. The correct dosage depends on your dog’s weight, and vets usually recommend 1.5 – 3.5 mg per pound.
A 100mg trazodone tablet is useful for medium and large dogs but must be adjusted carefully for smaller breeds. Always watch for side effects and never give trazodone without your vet’s guidance.
By understanding the dosage charts per pound and per kg, you can have an informed conversation with your veterinarian and ensure your dog receives the right care.